Beijing Insitute of Genomics
1. Based on the new high-throughput sequencing technology, the functions of newly identified epigenetic regulators were studied, and the regulation mechanism of novel nucleic acid modifications such as RNA m6A on gene expression was interpreted.
2.Interpreting the precise regulatory mechanism of RNA modification in the maintenance, transformation and reprogramming of embryonic stem cells. which is applied to stem cell medical science and tissue and organ regeneration.
3. To study the dynamic changes of epigenetic modification of tumor cells and immune cells in tumor microenvironment, and to elucidate the mechanism of tumor immune escape.
4. Develop machine learning and artificial intelligence algorithms, integrate epigenome, epigenome data and clinical medical information to accurately predict, diagnose and treat cancer, and realize intelligent medical treatment.