Dr. Jianhui Zhu


Email:zhujh(at)big.ac.cn


​Publications:
1. Siyuan Su, Xu Zhu, Liang Lin, Xianwei Chen, Yang Wang, Jin Zi, Yusheng Dong, Yingying Xie, Yinghui Zhu, Ju Zhang, Jianhui Zhu, Dan Xu, Ningzhi Xu, Xiaomin Lou*, Siqi Liu*, Lowering endogenous cathepsin D abundance results in reactive oxygen species accumulation and cell senescence, Molecular & Cellular Proteomics, 2017, 16(7):1217-1232.
2. Jianhui Zhu, Huijie Liu, Jia Zhang, Pan Wang, Siqi Liu, Guozhen Liu and Lin Wu*, Effects of Asn-33 glycosylation on the thermostability of Thermomyces lanuginosus lipase, Journal of Applied Microbiology, 2014, 117(1): 151-159
3. Shuang Liu, Jianhui Zhu, Liping He, Jun Dai, Huibin Lu*, Lin Wu*, Kuijuan Jin, Guozhen Yang, and Heng Zhu*, Label-free, real-time detection of the dynamic processes of protein degradation using oblique-incidence reflectivity difference method, Applied Physics Letters, 2014, 104(16): 163701.
4. Yinghao Cao, Jian Sun, Jianhui Zhu, Liyun Li, Guozhen Liu*, PrimerCE: designing primers for cloning and gene expression, Molecular Biotechnology, 2010, 46(2): 113-117
5. Qifeng Song#, Guozhen Liu#, Shaohui Hu, Yan Zhang, Yong Tao, Yuning Han, Haipan Zeng, Wei Huang, Fang Li, Peng Chen, Jianhui Zhu, Chaojun Hu, Shulan Zhang, Yongzhe Li*, Heng Zhu*, Lin Wu*, Novel autoimmune hepatitis-specific autoantigens identified using protein microarray technology, Journal of Proteome Research, 2010, 9(1):30-39.

Yawei Zhang

Bioinformatics

PhD Student

Zurui Huang

Bioinformatics

Recommended postgraduate

Research Associate


Dr. Renbao Chang


Publications:
1.Chang, R., Liu, X., Li, S., and Li, X.J. (2015). Transgenic animal models for study of the pathogenesis of Huntington’s disease and therapy. Drug. Des. Devel. Ther. 9, 2179-2188. 
2.Yin, P., Tu, Z., Yin, A., Zhao, T., Yan, S., Guo, X., Chang, R., Zhang, L., Hong, Y., Huang, X., Zhou, J., Wang, Y., Li, S., Li, X. (2015). Aged monkey brains reveal the role of ubiquitin-conjugating enzyme UBE2N in the synaptosomal accumulation of mutant huntingtin. Hum. Mol. Genet. 24, 1350-1362.
3.Yang, S., Chang, R., Yang, H., Zhao, T., Hong, Y., Kong, H. E., Sun, X., Qin, Z., Jin, P., Li, S., Li, X.. CRISPR/Cas9-mediated gene editing ameliorates neurotoxicity in mouse model of Huntington's disease. J. Clin. Invest. 2017 Jun 30;127(7)

PI: Dali Han

Scientific research secretary

Xiaoyun Zhang

​Genomics

​PhD Student

Postdoctoral Scholar

Dr. Jie Li

Email:lijie(at)big.ac.cn

Personal experience:

2007.9- 2011.6  Bachelor of pharmacy, school of pharmacy, Hebei Medical University.
2011.9- 2016.6  Doctor of chemical biology, school of pharmacy, Nankai University.
2016.11- 2018.12 Postdoctoral scholar, State Key Laboratory of Medicinal Chemical Biology, Nankai University.
2019.3- present  Research assistant,Beijing Institute of Genomics, Chinese Academy of Sciences.


Publications:

1.Li, J.; Bai, T. R.; Gao, S.; Zhou, Z.; Peng, X. M.; Zhang, L. S.; Dou, D. L.; Zhang, Z. S.; Li, L. Y., Human rhomboid family-1 modulates clathrin coated vesicle-dependent pro-transforming growth factor alpha membrane trafficking to promote breast cancer progression. EBioMedicine, 2018, 36, 229-240.
2.Li, J.; Liu, X.; Gao, Y.; Zong, G.; Wang, D.; Liu, M.; Fei, S.; Wei, Y.; Yin, Z.; Chen, J.; Wang, X.; Shen, Y., Identification of a UDP-Glucosyltransferase favouring substrate- and regio-specific biosynthesis of flavonoid glucosides in Cyclocarya paliurus. Phytochemistry, 2019, 163(C), 75-88.
3.Zong, G.; Fei, S.; Liu, X.; Li, J.; Gao, Y.; Yang, X.; Wang, X.; Shen, Y., Crystal structures of rhamnosyltransferase UGT89C1 from Arabidopsis thaliana reveal the molecular basis of sugar donor specificity for UDP-beta-l-rhamnose and rhamnosylation mechanism. Plant J., 2019. doi:10.1111/tpj.14321
4.Zong, G.; Li, J.; Gao, Y.; Fei, S.; Liu, X.; Wang, X.; Shen, Y., Overexpression, purification, biochemical and structural characterization of rhamnosyltransferase UGT89C1 from Arabidopsis thaliana. Protein Expr Purif., 2019, 156, 44-49.
5.Qi, J. W.; Qin, T. T.; Xu, L. X.; Zhang, K.; Yang, G. L.; Li, J.; Xiao, H. Y.; Zhang, Z. S.; Li, L. Y., TNFSF15 inhibits vasculogenesis by regulating relative levels of membrane-bound and soluble isoforms of VEGF receptor 1. Proc Natl Acad Sci U S A., 2013, 110 (34), 13863-8.
6.Song Chao, He Jie, Li Jie, Zhao Hongyi, Fu Yan. Research progress on sodium borohydride reduction system of carboxylic acid and its derivatives[J]. Chemistry, 2012, 75(07): 614-620.
7.Song Chao, He Jie, Li Jie, Zhao Hongyi, Fu Yan. Catalytic synthesis of sodium borohydride of cyclohexylmethylamine [J]. Chemical reagents, 2012, 34(06): 555-558.

Patent:

Li Luyuan, Zhang Zhisong, Dou Daolei, Li Jie, Shu Feifei, Zheng Yangyang. Peptides that inhibit the stability of HIF1α and their applications: China, CN 104877030, [P]. 2015-09-02.

Graduate Students

Guanghao Liang

Genomics

Master Student

Personal experience: 
2003- 2007: B.S, University of Science and Technology of China
2007- 2012: Ph.D, in Bioinformatics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
2012- 2017: postdoctoral scholar at the University of Chicago
2017-present: Beijing Institute of Genomics, Chinese Academy of Sciences, 
Principal Investigator


Research Interests:
DNA and RNA epigenetics
Tumor Immunology Genomics
Bioinformatics


​Email:handl(at)big.ac.cn


Linchen Wang

Bioinformatics

PhD Student

Haochen Ni

Bioinformatics

Master Student

Yin Xu

Genomics

Master Student

Fangle Li

Genomics

PhD Student

Chuanyuan Chen

Bioinformatics

PhD Student

Minghui Gong

Genomics

Recommended postgraduate

Chuandong Liu

Bioinformatics

Master Student