Personal experience: 
2003- 2007, B.S. , University of Science and Technology of China
2007- 2012, Ph.D. , in Bioinformatics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
2012- 2017, postdoctoral scholar at the University of Chicago
2017-present, Beijing Institute of Genomics, Chinese Academy of Sciences, 
Principal Investigator


Research Interests:
DNA and RNA epigenetics
Tumor Immunology Genomics
Bioinformatics


​Email:handl(at)big.ac.cn

Dr. Jianhui Zhu


Email:zhujh(at)big.ac.cn


​Publications:
1.Siyuan Su, Xu Zhu, Liang Lin, Xianwei Chen, Yang Wang, Jin Zi, Yusheng Dong, Yingying Xie, Yinghui Zhu, Ju Zhang, Jianhui Zhu, Dan Xu, Ningzhi Xu, Xiaomin Lou*, Siqi Liu*. Lowering endogenous cathepsin D abundance results in ROS accumulation and cell senescence. Molecular & Cellular Proteomics. 2015, pii: mcp.M115.050179.
2.J. Zhu, H. Liu, J. Zhang, P. Wang, S. Liu, G. Liu and L. Wu. Effects of Asn-33 glycosylation on the thermostability of Thermomyces lanuginosus lipase. Journal of Applied Microbiology. 117, 151—159, 2014
3.S. Liu, J. H. Zhu, L. P. He, J. Dai, H. B. Lu, L. Wu, K. J. Jin, G. Z. Yang, and H. Zhu. Label-free, real-time detection of the dynamic processes of protein degradation using oblique-incidence reflectivity difference method. Applied Physics Letters. 104, 163701 , 2014
4.Cao, Yinghao; Sun, Jian; Zhu, Jianhui; Li, Liyun; Liu, Guozhen. PrimerCE: Designing Primers for Gene Cloning and Protein Expression. Molecular Biotechnology: Volume 46, Issue 2, Page 113, 2010
5.Song Q, Liu G, Hu S, Zhang Y, Tao Y, Han Y, Zeng H, Huang W, Li F, Chen P, Zhu J, Hu C, Zhang S, Li Y, Zhu H, Wu L. Novel Autoimmune Hepatitis-Specific Autoantigens Identified Using Protein Microarray Technology. Journal of Proteome Research  Jan;9(1):30-9,2010

Xiaoyun Zhang

Yawei Zhang


Siqi Zhao

Dr. Renbao Chang


Publications:
1.Chang, R., Liu, X., Li, S., and Li, X.J. (2015). Transgenic animal models for study of the pathogenesis of Huntington’s disease and therapy. Drug. Des. Devel. Ther. 9, 2179-2188. 
2.Yin, P., Tu, Z., Yin, A., Zhao, T., Yan, S., Guo, X., Chang, R., Zhang, L., Hong, Y., Huang, X., Zhou, J., Wang, Y., Li, S., Li, X. (2015). Aged monkey brains reveal the role of ubiquitin-conjugating enzyme UBE2N in the synaptosomal accumulation of mutant huntingtin. Hum. Mol. Genet. 24, 1350-1362.
3.Yang, S., Chang, R., Yang, H., Zhao, T., Hong, Y., Kong, H. E., Sun, X., Qin, Z., Jin, P., Li, S., Li, X.. CRISPR/Cas9-mediated therapeutic effects in Huntington’s disease mice. J. Clin. Invest. Online. (co-first author)

PI: Dali Han

Staff

Beijing Insitute of Genomics

Chuanyuan Chen

Linchen Wang

Xuemin Dong

Graduate Students


Postdoctoral Scholar

Xiuzhi Wang

Fangle Li